منابع مشابه
When more is not more
oosting the function of a learning protein jams the brain with too much information, according to Ype Elgersma (Erasmus MC, Rotterdam, Netherlands), Alcino Silva (University of California, Los Angeles, CA), and colleagues. The result is a cautionary tale for those seeking to develop learning drugs. The team created mice lacking two inhibitory phosphorylation sites on CaMKII. Wild-type CaMKII is...
متن کاملWhen Less is More
engine and airframe manufacturers for decades have cited the direct relationship between engine wear and high exhaust gas temperature (EGT) in recommending that operators use less than maximum takeoff thrust whenever possible. While the cost benefits of reduced-thrust takeoffs are thoroughly documented, the safety benefits are not as well understood. Thus, there is a common perception that usin...
متن کاملWhen more is better
Nutrition support of critically ill patients with sepsis is one of the most debated issues among intensivists. The latest international sepsis guidelines recommend the prescription of a low volume of feeds through gastric or intestinal enteral nutrition (EN) for 7 days after admission to the ICU. The data to support such recommendations are scarce, and large trials are needed to clarify this is...
متن کاملWhen Less is More.
minimum level. Sometimes more really is more, and less really is less. But often, less is more. If all this piece does is open up the question of whether less is more —if all it does is remind the reader that this is a question, and that our answers to it have important repercussions— then it will have served its purpose. Many ethicists in the ancient tradition argued that human lives could be ...
متن کاملWhen Is More Not Better?
It is often assumed that when sensing in autonomous robot navigation, the more measurements taken, the better. In many cases, this is indeed true. However, we have found that in an outdoor, unstructured environment where the number of possible measurements one can take is limited and error is not normally distributed, additional measurements may cause more harm than good. These “rogue” measurem...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2006
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg1842